Quantification of TB-500 and metabolites by high-resolution MS
Rahaman KA, et al. · Journal of Chromatography B · 2024 · Analytical/preclinical
Quantifies TB-500 and its metabolites by high-resolution MS and screens wound-healing activity in vitro.
Peptide fragment (Thymosin β4)
A synthetic fragment of Thymosin β4 studied for cell migration and tissue repair.
At a glance
Overview
Based on the actin-regulating region of Thymosin β4, a protein found in nearly all cells.
Studied for wound healing, angiogenesis and cardiac repair. Often paired with BPC-157 in recovery research.
Mechanism
Regulates actin, promoting cell migration, angiogenesis and reduced inflammation at injury sites.
Research
Rahaman KA, et al. · Journal of Chromatography B · 2024 · Analytical/preclinical
Quantifies TB-500 and its metabolites by high-resolution MS and screens wound-healing activity in vitro.
ClinicalTrials.gov (NCT07586865) · Clinical trial registry · 2026 · Clinical trial registry
A currently registered human trial applying recombinant Thymosin β4 in heart-attack patients; outcomes pending.
Zhu J, et al. · Cytotherapy · 2016 · Human
Thymosin β4-pretreated cell transplantation in STEMI patients; small early-phase safety/efficacy signal.
Malinda KM, et al. · FASEB Journal · — · Foundational
Showed Thymosin β4 accelerates re-epithelialisation and wound closure; the mechanistic bedrock for later TB-500 work.
Song K, et al. · European Journal of Pharmacology · 2020 · Preclinical
Thymosin β4 protected human brain endothelial cells from prion-fragment toxicity, supporting a neuroprotective angle.
Evidence summary
Grounded in the well-established biology of Thymosin β4, a repair protein found in nearly every cell, with a strong preclinical foundation in wound healing, cell migration and cardiac repair. Human research is now advancing, including a newly registered clinical trial - a compound moving steadily from established science toward the clinic.